Intramuscular administration of AAV overcomes pre-existing neutralizing antibodies in rhesus macaques
نویسندگان
چکیده
منابع مشابه
A vaccine based on the rhesus cytomegalovirus UL128 complex induces broadly neutralizing antibodies in rhesus macaques.
Neutralizing antibodies (NAb) are important for interfering with horizontal transmission of human cytomegalovirus (HCMV) leading to primary and congenital HCMV infection. Recent findings have shown that a pentameric virion complex formed by the glycoproteins gH/gL, UL128, UL130, and UL131A (UL128C) is required for HCMV entry into epithelial/endothelial cells (Epi/EC) and is the target of potent...
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ژورنال
عنوان ژورنال: Vaccine
سال: 2016
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2016.10.053